Our lab is broadly interested in applying chemical biology to investigate gene regulation. We develop chemical and molecular biology tools to allow new measurements and perturbations in biological systems. We use these tools with other chemical and genetic approaches to study mechanisms of gene regulation and dysregulation in cancer.
Chemical Approaches for functional genomics
We are developing chemical probes and molecular biology tools leveraged with next-generation sequencing to study chromatin conformation, transcription, and translation in small numbers of cells — with single cells as an ultimate goal. Our long-term objective is to apply these methods to investigate gene regulation in rare, primary cells off limits to current technology.
We are interested in studying the mechanisms of cancer mutations that disrupt chromatin regulation. In particular, we focus on key mutations that perturb the chemical etiology of chromatin post-translational modifications. We combine genetic approaches with chemical probes and concepts to investigate these mechanisms, with the long-term aim of uncovering therapeutic opportunities.
We are interested in the chemical synthesis of small molecules and their functional derivatives that interconnect and enable the above research areas. These probe molecules will be derived both rationally and also from natural products.