PUBLICATIONS

Bold indicates authors from the Liau Lab

2. Park, Y., Koga, Y., Waterbury, A.L., Su, C., Johnny, C.L., Liau, B.B**. A Versatile Synthetic Route to Cycloheximide and Analogs that Potently Inhibit Translation Elongation. Submitted.

1. Vinyard, M.E., Su, C., Siegenfeld, A.P., Waterbury, A.L., Freedy, A.M., Gosavi, P.M., Park, Y., Kwan, E.E., Senzer, B.D., Doench, J.G., Bauer, D.E., Pinello, L., Liau, B.B**. CRISPR-suppressor scanning reveals a non-enzymatic role of LSD1 in AML. Accepted in principle.

COMMENTARIES

Park, Y., Liau, B.B**. Uncovering the Cellular Target of Agelastatin A. Cell Chemical Biology 24, 542–543 (2017). (pdf)

Graduate & postdoctoral

Miller, T.E., Liau, B.B., Wallace, L.C., Morton, A.R., Xie, Q., Dixit, D., Factor, D.C., Kim, L.Y.J., Morrow, J.J., Wu, Q., Mack, S.C., Hubert, C.G., Gillespie, S.M., Flavahan, W.A., Hoffmann, T., Thummalapalli, R., Hemann, M.T., Paddison, P.J., Horbinski, C.M., Zuber, J., Scacheri, P.C., Bernstein, B.E., Tesar, P.J., Rich, J.N. Transcription elongation factors represent in vivo cancer dependencies in glioblastoma. Nature 547, 355-359 (2017).

Liau, B.B.*, Sievers, C.*, Donohue, L.K., Gillespie, S.M., Flavahan, W.A., Miller, T.E., Venteicher, A.S., Hebert, C.H., Carey, C.D., Rodig, S.J., Shareef, S.J., Najm, F.J., van Galen, P., Wakimoto, H., Cahill, D.P., Rich, J.N., Aster, J.C., Suvà, M.L., Patel, A.P., Bernstein, B.E. Adaptive chromatin remodeling drives glioblastoma stem cell plasticity and drug tolerance. Cell Stem Cell 20, 233–246 (2017).

Xie, Q., Wu, Q., Kim., L., Miller, T.E., Liau, B.B., Mack, S.C., Yang, K., Factor, D.C., Fang, X., Huang, Z., Zhou, W., Alazem, K., Wang, X., Bernstein, B.E., Bao, S., Rich, J.N. RBPJ maintains brain tumor-initiating cells through CDK9-mediated transcriptional elongation. Journal of Clinical Investigation 126, 2757–2772 (2016).

Flavahan, W.A.*, Drier, Y.*, Liau, B.B., Gillespie, S.M., Venteicher, A.S., Stemmer-Rachamimov, A.O., Suvà, M.L., Bernstein, B.E. Insulator dysfunction and oncogene activation in IDH mutant gliomas. Nature 529, 110–114 (2016).

van Galen, P., Viny, A.D., Ram, O., Ryan, R.J.H., Cotton, M.J., Donohue, L., Sievers, C., Drier, Y., Liau, B.B., Gillespie, S.M., Carroll, K.M., Cross, M.B., Levine, R.L., Bernstein, B.E. A multiplexed system for quantitative comparisons of chromatin landscapes. Molecular Cell 61, 170–180 (2016).

Pelish, H.E.*, Liau, B.B.*, Nitulescu, I.I., Tangpeerachaikul, A., Poss, Z.C., Da Silva, D.H., Caruso, B.T., Arefolov, A., Fadeyi, O., Christie, A.L., Du, K., Banka, D., Schneider, E.V., Jestel, A., Zou, G., Si, C., Ebmeier, C.C., Bronson, R.T., Krivtsov, A.V., Myers, A.G., Kohl, N.E., Kung, A.L., Armstrong, S.A., Lemieux, M.E., Taatjes, D.J., Shair, M.D. Mediator kinase inhibition further activates super-enhancer-associated genes in AML. Nature 526, 273–276 (2015).

Lee, A.S., Liau, B.B., Shair, M.D. A unified strategy for the synthesis of 7-membered-ring-containing Lycopodium alkaloids. Journal of the American Chemical Society 136, 13442–13452 (2014).

Liau, B.B., Milgram, B.C., Shair, M.D. Total syntheses of HMP-Y1, hibarimicinone, and HMP-P1. Journal of the American Chemical Society 134, 16765–16772 (2012).

Milgram, B.C., Liau, B.B., Shair, M.D. Gram-scale synthesis of the A'B'-subunit of angelmicin B. Organic Letters 13, 6436–6439 (2011).

Liau, B.B., Shair, M.D. Total synthesis of (+)-fastigiatine. Journal of the American Chemical Society 132, 9594–9595 (2010).

Liau, B.B., Gnanadesikan, V., Corey, E.J. A study of the effect of Z- and E-olefinic geometry on the rates of ring closure of 13-membered dienes. Organic Letters 10, 1055–1057 (2008).