Brian grew up in Belmont, MA and graduated from Harvard College in 2007, conducting undergraduate research with EJ Corey. He later received his Ph.D. in Chemistry from Harvard in 2013 under the guidance of Matt Shair. There, he first worked on the total synthesis of complex natural products. Fascinated by their biological functions, the latter part of his Ph.D. work focused on the chemical biology associated with the natural product cortistatin A, a potent inhibitor of the Mediator kinases: CDK8 and CDK19. From 2013 to 2016, Brian was a post-doctoral fellow with Bradley Bernstein at Massachusetts General Hospital, where he studied epigenomic mechanisms of adaptation and drug resistance in brain cancer.
Brian started as an assistant professor at the Harvard Department of Chemistry and Chemical Biology in 2016, where his lab is investigating chromatin-mediated mechanisms in cancer using chemistry and functional genomics.